Journal
PLANTA MEDICA
Volume 70, Issue 5, Pages 465-467Publisher
GEORG THIEME VERLAG KG
DOI: 10.1055/s-2004-818977
Keywords
-
Ask authors/readers for more resources
The mechanism underlying the vasodilator effect of the flavonoid floranol was studied in rat small mesenteric arteries. Floranol produced a concentration-dependent vasorelaxant effect in endothelium-containing and endothelium-denuded vessels precontracted with phenylephrine, which was more potent in endothelium-intact vessels. In endothelium-intact mesenteric arteries, I-NAME but not indomethacin produced a shift to the right in the vasorelaxant effect of floranol. In endothelium-denuded vessels TEA and BaCl2 did not change the floranol-induced vasorelaxation. When endothelium-denuded vessels were pre-contracted with 50 mM KCl, floranol induced a vasorelaxant effect comparable with phenylephrine pre-contracted vessels. We conclude that floranol is a new vasodilator compound in rat small mesenteric arteries. Part of this effect is dependent on endothelial nitric oxide (NO) and part is dependent on the inhibition of voltage-dependent Calcium channels in the smooth muscle cells.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available