Journal
JOURNAL OF NEUROIMMUNOLOGY
Volume 150, Issue 1-2, Pages 20-28Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jneuroim.2004.01.005
Keywords
amyloid-beta; oxidative stress; neuroinflammatory response; kinetics; cytokine; interleukin; tumor necrosis factor
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The purpose of this study was to describe-following the injection of a single intracerebral dose of fibrillar amyloid-beta(1-40) in vivo-some correlations between proinflammatory cytokines and oxidative stress indicators in function of time, as well as how these variables fit in a regression model. We found a positive, significant correlation between interleukin (IL)-1beta or IL-6 and the activity of the glutathione peroxidase enzyme (GSH-Px), but IL-1beta or IL-6 maintained a strong, negative correlation with the lipid peroxidation (LPO). The first 12 It marked a positive correlation between IL-6 and tumor necrosis factor-alpha (TNF-alpha), but starting from the 36 h, this relationship became negative. We found also particular patterns of behavior through the time for IL-1beta, nitrites and IL-6, with parallel or sequential interrelationships. Results shows clearly that, in vivo, the fibrillar amyloid-beta (Abeta) disrupts the oxidative balance and initiate a proinflammatory response, which in turn feeds the oxidative imbalance in a coordinated, sequential way. This work contributes to our understanding of the positive feedbacks, focusing the cytokine cycle along with the oxidative stress mediators in a complex, multicellular, and interactive environment. (C) 2004 Elsevier B.V. All rights reserved.
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