Journal
JOURNAL OF NEUROIMMUNOLOGY
Volume 150, Issue 1-2, Pages 157-162Publisher
ELSEVIER
DOI: 10.1016/j.jneuroim.2004.01.013
Keywords
Sydenham's chorea; cytokines; chemokines; CXCL9; CXCL10
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Sydenham's chorea (SC) is thought to result from the action of streptococcus-induced antibodies that cross react with basal ganglia antigens. Much less is known, however, about the involvement of cellular mechanisms in its pathogenesis. Since chemokines seem to play a role in several CNS inflammatory disorders, we sought to investigate the chemokine profile of patients with SC. Increased serum levels of CXCL9, formerly monokine induced by interferon-gamma (Mig), and CXCL10, formerly interferon-gamma-inducible protein of 10 kDa (IP-10) were demonstrated in acute SC patients, suggesting that a particular group of chemokines may be involved in SC pathogenesis. (C) 2004 Elsevier B.V. All rights reserved.
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