Journal
MARINE BIOTECHNOLOGY
Volume 6, Issue 3, Pages 215-220Publisher
SPRINGER
DOI: 10.1007/s10126-003-0010-z
Keywords
antibiotic; production; marine natural products; cyclo(Phe-Pro)
Funding
- NIGMS NIH HHS [S06 GM59833-01] Funding Source: Medline
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Thirteen bacterial strains isolated from a sample of Ulva californica were cultured, extracted, and assayed for antibiotic activity. The target strains were 2 gram-positive isolates from the same algal sample. When cultured in monoculture, 2 of the 13 isolates produced extracts with antimicrobial activity. More significantly, one Bacillus isolate (UA-094) produced indole and cyclo(Phe-Pro) at active levels upon challenge with a different Bacillus target strain. These mildly antibiotic compounds were barely detectable in extracts without challenge. This technique of competitive induction and enhancement could be a valuable tool in the search for new antibiotics.
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