Journal
DRUG METABOLISM REVIEWS
Volume 36, Issue 2, Pages 279-299Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1081/DMR-120034001
Keywords
aldehyde dehydrogenases; human; metabolism; lipid peroxidation; polymorphisms
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Funding
- NEI NIH HHS [EY11490] Funding Source: Medline
- NIAAA NIH HHS [AA11885] Funding Source: Medline
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The human genome contains at least 17 genes that are members of the aldehyde dehydrogenase (ALDH) superfamily. These genes encode NAD(P)(+)-dependent enzymes that oxidize a wide range of aldehydes to their corresponding carboxylic acids. Aldehydes are highly reactive molecules that are intermediates or products involved in a broad spectrum of physiologic, biologic, and pharmacologic processes. Aldehydes are generated during retinoic acid biosynthesis and the metabolism of amino acids, lipids, carbohydrates, and drugs. Mutations in several ALDH genes are the molecular basis of inborn errors of metabolism and contribute to environmentally induced diseases.
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