Journal
ANNALS OF NEUROLOGY
Volume 55, Issue 5, Pages 744-748Publisher
WILEY-LISS
DOI: 10.1002/ana.20108
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Funding
- NCRR NIH HHS [P41-RR14075] Funding Source: Medline
- NIBIB NIH HHS [1R01 EB002459-01] Funding Source: Medline
- NINDS NIH HHS [K08 NS02067-01] Funding Source: Medline
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Although previous studies of focal hand dystonia have detected cortical sensorimotor abnormalities, little is known about the role of the basal ganglia in this disorder. We report here that when focal hand dystonic patients performed finger-tapping tasks, functional magnetic resonance imaging showed persisting elevations of basal ganglia activity after the tasks ended. We posit that inhibitory control of the basal ganglia may be faulty in focal hand dystonia, and that the increases we observe in resting activity may mask basal ganglia abnormalities in standard imaging contrast analyses.
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