Journal
BIOORGANIC & MEDICINAL CHEMISTRY
Volume 12, Issue 9, Pages 2193-2197Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmc.2004.02.020
Keywords
malvaceae; Hibiscus taiwanensis; lignan; 9,9 '-O-feruloyl-(-)-secoisolaricinresinol
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The separation of an extract prepared from the stems of the previously uninvestigated Hibiscus taiwanensis led to the isolation of three new phenylpropanoid esters, (7S,8S)-demethylcarolignan E (1), hibiscuwanin A (2), hibiscuwanin B (3), in addition to eight known ones. The structures of these compounds were elucidated by spectroscopic and chemical transformation studies. In cytotoxicity evaluation of the isolates, 9,9'-0-feruloyl-(-)-secoisolaricinresinoI (8) showed strong cytotoxic activity against human lung carcinoma and breast carcinoma cell lines in an in vitro cytotoxicity assay with EC50 values of 1.8 and 3.9 mug/ mL, respectively, (C) 2004 Elsevier Ltd. All rights reserved.
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