Journal
GENETICS
Volume 167, Issue 1, Pages 263-273Publisher
GENETICS SOC AM
DOI: 10.1534/genetics.167.1.263
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Funding
- NIGMS NIH HHS [R01 GM061252, GM61252, R01 GM061252-03] Funding Source: Medline
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Drosophila mei-9 is essential for several DNA repair and recombination pathways, including nucleotide excision repair (NER), interstrand crosslink repair, and meiotic recombination. To better understand the role of MEI-9 in these processes, we characterized 10 unique mutant alleles of mei-9. These include a P-clement insertion that disrupts repair functions but not the meiotic function; three nonsense mutations, one of which has nearly wild-type levels of protein; three missense mutations, one of which disrupts the meiotic function but not repair functions; two small in-frame deletions; and one frameshift.
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