Journal
JOURNAL OF INFECTIOUS DISEASES
Volume 189, Issue 9, Pages 1676-1678Publisher
OXFORD UNIV PRESS INC
DOI: 10.1086/382892
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Funding
- NIAID NIH HHS [R21 AI055278, R01 AI44594] Funding Source: Medline
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Although primary genomic analysis has revealed that severe acute respiratory syndrome coronavirus (SARS CoV) is a new type of coronavirus, the different protein trees published in previous reports have provided no conclusive evidence indicating the phylogenetic position of SARS CoV. To clarify the phylogenetic relationship between SARS CoV and other coronaviruses, we compiled a large data set composed of 7 concatenated protein sequences and performed comprehensive analyses, using the maximum-likelihood, Bayesian-inference, and maximum-parsimony methods. All resulting phylogenetic trees displayed an identical topology and supported the hypothesis that the relationship between SARS CoV and group 2 CoVs is monophyletic. Relationships among all major groups were well resolved and were supported by all statistical analyses.
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