Journal
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
Volume 28, Issue 5, Pages 415-428Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.dci.2003.09.016
Keywords
cytokine; interleukin-1; interleukin-1 receptors; toll; toil like receptor
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Interleukin-1 is a key inflammatory cytokine that mediates its effects through a type I receptor and a receptor accessory protein. These two molecules are members of a wider family of proteins that have in common the presence of immunoglobulin domains in the extracellular region of the protein and a TIR domain in the cytoplasmic region. The nature of this family of proteins and their signal transduction pathway is discussed in this review. (C) 2003 Elsevier Ltd. All rights reserved.
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