Journal
VACCINE
Volume 22, Issue 15-16, Pages 1914-1920Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.vaccine.2003.11.016
Keywords
measles vaccine; humoral immunity; HLA genes
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Funding
- NCRR NIH HHS [M01-RR-00585-25] Funding Source: Medline
- NIAID NIH HHS [R01-2AI-33144, N01-AI-45240] Funding Source: Medline
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Associations between human leukocyte antigen (HLA) genes and very high levels of antibodies (or hyperseroresponsiveness) to measles antigens in a genetically heterogeneous human population are poorly understood. We studied the association between antibody levels after measles vaccination and HLA class I and II alleles among 170 US schoolchildren who received one dose of measles-mumps-rubella 11 vaccine. Vaccine recipients were divided into two groups: 93 recipients who were seropositive and 77 recipients who were hyperseropositive (the upper 10th percentile of antibody levels of all subjects). Out of all the alleles analyzed, HLA-B*7 (odds ratio (OR) 1.9; P = 0.05), DQA1*0104 (OR 4.6; P = 0.02) and DPA1*0202 (OR 4.8; P = 0.04) alleles were positively associated with hyperseropositivity, whereas HLA-B*44 (OR 0.4; P = 0.02), DRB1*01 (OR 0.6; P = 0.09), DRB1*08 (OR 0.3; P = 0.04), DQB1*0301 (OR 0.5; P = 0.04), and DPB1*0401 (OR 0.6; P = 0.03) alleles were negatively associated with hyperseropositivity. The alleles B*44, DRB1*01, DRB1*08 and DQA1*0104 remained statistically significant after accounting for the effects of other alleles. The results suggest that HLA alleles have important associations with measles antibody hyperseropositivity. These data increase our understanding of measles vaccine-induced immune response and will be useful for future mechanistic work on measles virus antigen processing and presentation in seronegative and hyperseropositive individuals. (C) 2003 Elsevier Ltd. All rights reserved.
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