Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 101, Issue 19, Pages 7352-7356Publisher
NATL ACAD SCIENCES
DOI: 10.1073/pnas.0402009101
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Funding
- NIAID NIH HHS [T32 AI 07334, T32 AI007334] Funding Source: Medline
- NIA NIH HHS [R01 AG020684, AG 20684] Funding Source: Medline
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DNA mutagenesis is generally considered harmful. Yet activated B cells normally mutate the Ig loci. Because this somatic hypermutation is potentially dangerous, it has been hypothesized that mutations do not occur throughout the genome but instead are actively targeted to the Ig loci. Here we challenge this long-standing and widely accepted hypothesis. We demonstrate that hypermutation requires no Ig gene sequences. Instead, activation-induced cytidine deaminase and other trans-acting hypermutation factors may function as general mutators.
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