Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 101, Issue 19, Pages 7329-7334Publisher
NATL ACAD SCIENCES
DOI: 10.1073/pnas.0401648101
Keywords
-
Categories
Funding
- NIAID NIH HHS [R01 AI 16567, N01 AI 05406, R01 AI046351, R01 AI 46351, R01 AI016567] Funding Source: Medline
- NIDCR NIH HHS [P01 DE 07946, DE 12302-02S2, P01 DE007946, R01 DE 12940] Funding Source: Medline
Ask authors/readers for more resources
We present the diploid genome sequence of the fungal pathogen Candida albicans. Because C albicans has no known haploid or homozygous form, sequencing was performed as a whole-genome shotgun of the heterozygous diploid genome in strain SC5314, a clinical isolate that is the parent of strains widely used for molecular analysis. We developed computational methods to assemble a diploid genome sequence in good agreement with available physical mapping data. We provide a whole-genome description of heterozygosity in the organism. Comparative genomic analyses provide important clues about the evolution of the species and its mechanisms of pathogenesis.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available