Journal
ORGANIC LETTERS
Volume 6, Issue 10, Pages 1661-1664Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol049495d
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- FIC NIH HHS [U01TW-01021-01] Funding Source: Medline
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Bielschowskysin is a naturally occurring diterpene isolated from the Caribbean gorgonian octocoral Pseudopterogorgia kallos. Its highly oxygenated hexacyclic structure is based on a previously undescribed tricyclo[9.3.0.0(2,10)]tetradecane ring system that was established through spectroscopic analysis and X-ray crystallographic analysis. Bielschowskysin was shown to exhibit antimalarial activity against Plasmodium falciparum as well as strong anticancer activity against two human cancer cell lines.
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