Journal
OPTICS LETTERS
Volume 29, Issue 10, Pages 1087-1089Publisher
OPTICAL SOC AMER
DOI: 10.1364/OL.29.001087
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We demonstrate the capability of differential path-length spectroscopy (DPS) to determine the local optical properties of tissue in vivo. DPS measurements on bronchial mucosa are analyzed and yield information on the local blood oxygenation, blood content, average microvessel diameter, and wavelength dependence of the reduced scattering coefficient. Our data collected to date show that cancerous bronchial mucosa has a lower capillary oxygenation and a larger average capillary diameter than normal bronchial mucosa. (C) 2004 Optical Society of America
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