Journal
IMMUNOLOGY LETTERS
Volume 93, Issue 2-3, Pages 109-113Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.imlet.2004.03.014
Keywords
T lymphocyte; trafficking; endothelial cells; antigen presentation
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The functional consequences of recognition of antigen displayed by the endothelium during T cell extravasation in the development of an immune response have been a matter of debate for a long time. Most investigations have focused on the induction of proliferative responses and cytokine production by T cells. In parallel, endothelial cells have been shown to express costimulatory molecules with positive and negative regulatory effects on T cell responses. Recent studies have provided an alternative view of the antigen presenting cell function of endothelial cells, suggesting that cognate recognition of the endothelium by trafficking T cells is a key event in selecting the migration of antigen-specific lymphocytes into the site of inflammation. (C) 2004 Elsevier B.V. All rights reserved.
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