Journal
JOURNAL OF THE NEUROLOGICAL SCIENCES
Volume 220, Issue 1-2, Pages 73-78Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jns.2004.02.008
Keywords
metalloproteinase; tuberculous meningitis; aseptic meningitis; cerebrospinal fluid; ELISA; zymography
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Matrix metalloproteinase (MMP)-2 and MMP-9 were analyzed by gelatin zymography and an enzyme-linked immunosorbent assay (ELISA) in a cerebrospinal fluid (CSF) from patients with tuberculous meningitis (n=24), acute aseptic meningitis (n=23) and the control (n=10). The MMP-2 and MMP-9 levels were significantly higher in the samples from the tuberculous meningitis patients than those from either the aseptic meningitis patients or the controls. In tuberculous meningitis, the patients with late neurologic complications had higher MMP-2 and MMP-9 levels than those without. The persistent increase in the MMP-2 and MMP-9 levels was associated with the development of complications following tuberculous meningitis. Inhibiting the MMPs may be an effective strategy for preventing or reducing the complications in tuberculous meningitis. (C) 2004 Elsevier B.V. All rights reserved.
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