Journal
OPTICS LETTERS
Volume 29, Issue 10, Pages 1090-1092Publisher
OPTICAL SOC AMER
DOI: 10.1364/OL.29.001090
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Funding
- NCRR NIH HHS [RR-01192] Funding Source: Medline
- NIBIB NIH HHS [EB-00293] Funding Source: Medline
- NCPDCID CDC HHS [NCI-91717] Funding Source: Medline
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Second-harmonic optical coherence tomography, which uses coherence gating of second-order nonlinear optical responses of biological tissues for imaging, is described and demonstrated. Femtosecond laser pulses were used to excite second-harmonic waves from collagen harvested from rat tail tendon and a reference nonlinear crystal. Second-harmonic interference fringe signals were detected and used for image construction. Because of the strong dependence of second-harmonic generation on molecular and tissue structures, this technique imparts contrast and resolution enhancement to conventional optical coherence tomography. (C) 2004 Optical Society of America
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