Journal
REGULATORY PEPTIDES
Volume 118, Issue 3, Pages 183-191Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.regpep.2003.12.014
Keywords
central amygdaloid nucleus; cold exposure; CRF; Fos; immobilized stress; orexin; paraventricular nucleus
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We examined the effects of centrally administered orexin-A on corticotropin-releasing factor (CRF)-containing neurons in the hypothalamic paraventricular nucleus (PVN) and the central amygdaloid nucleus (CeA) of rats, using dual immunostaining for CRF and Fos. Ninety minutes after intracerebroventricular administration of orexin-A, approximately 96% and 45% of CRF-containing neurons expressed Fos-like immunoreactivity (LI) in the PVN and the CeA, respectively. We also examined the effects of immobilized stress and cold exposure on orexin-A-containing neurons in the rat hypothalamus using dual immunostaining for orexin-A and Fos. After immobilized stress for 20 min and cold exposure at 4 degreesC for 30 min, approximately 24% and 15% of orexin-A-containing neurons expressed Fos-LI, respectively. These results suggest that orexins in the central nervous system may be involved in the activation of central CRF neurons induced by stress. (C) 2004 Elsevier B.V. All rights reserved.
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