Journal
NEUROREPORT
Volume 15, Issue 7, Pages 1171-1175Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/00001756-200405190-00018
Keywords
adenoviral; CREB; glutamate; hippocampal; ischemia; neurodegeneration
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Funding
- Biotechnology and Biological Sciences Research Council [C18365] Funding Source: researchfish
- Biotechnology and Biological Sciences Research Council [C18365] Funding Source: Medline
- Wellcome Trust [069280] Funding Source: Medline
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In this study we have used a molecular approach to manipulate CREB gene expression to study its role in the regulation of neuronal cell death. To achieve this, adenoviral (Ad) vectors encoding EGFP, CREB, and a powerful CREB dominant-negative, known as A-CREB were constructed. The over-expression of CREB but not A-CREB was found to protect primary hippocampal neurons from staurosporine-induced apoptosis, glutamate induced excitotoxicity and exposure to an in vitro ischaemic stress. Hence, manipulating CREB-regulated pathways may provide a means of delaying or preventing the neuronal cell death associated with ischaemic related injury, and in neurodegenerative diseases such as Huntington's and Alzheimer's disease.
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