Journal
JOURNAL OF MEDICINAL CHEMISTRY
Volume 47, Issue 11, Pages 2724-2727Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jm049968m
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2-Aryl-3-pyrimidinyl based tumor necrosis factor-alpha (TNF-alpha) inhibitors, which contain a novel bicyclic pyrazolope core, are described. Many showed low-nanomolar activity against lipopolysaccharide-induced TNF-alpha production in monocytic cells. Secondary screening data are presented for the pyrimidinyl bicyclic pyrazolones. Several of these analogues showed good oral bioavailability in rat and efficacy in the rat iodoacetate in vivo model.
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