Journal
NEUROSCIENCE LETTERS
Volume 362, Issue 2, Pages 95-98Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neulet.2004.03.006
Keywords
Alzheimer's disease; subcortical ischemic vascular dementia; motor cortex excitability; transcranial magnetic stimulation
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Twenty Alzheimer's disease (AD) patients, 20 subcortical ischemic vascular dementia (SIVD) patients and 20 neurologically and cognitively normal subjects underwent transcranial magnetic stimulation to study motor cortex excitability changes. Motor threshold (NIT), amplitude of motor evoked potentials, silent period and the H/M ratio (amplitude of maximal Hoffman reflex vs. that of maximal motor response) were considered. MT was lower in SIVD patients when compared with AD patients (P = 0.003) and the control group (P < 0.001) and lower in AD patients when compared with the control group (P < 0.001). The increment of motor cortex excitability in AD and SIVD did not lead us to distinguish clearly the two types of dementia. It is likely that the electrophysiological similarity between AD and SIVD could represent another common mechanism shared from these forms of dementia. (C) 2004 Elsevier Ireland Ltd. All rights reserved.
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