Journal
FEBS LETTERS
Volume 566, Issue 1-3, Pages 131-135Publisher
WILEY
DOI: 10.1016/j.febslet.2004.04.032
Keywords
telomere; nucleosomal array; atomic force microscopy; theoretical modeling; nucleosome positioning
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Telomeric chromatin has peculiar features with respect to bulk chromatin, which are not fully clarified to date. Nucleosomal arrays, reconstituted on fragments of human telomeric DNA and on tandemly repeated tetramers of 5S rDNA, have been investigated at single-molecule level by atomic force microscopy and Monte Carlo simulations. A satisfactory correlation emerges between experimental and theoretical internucleosomal distance distributions. However, in the case of telomeric nucleosomal arrays containing two nucleosomes, we found significant differences. Our results show that sequence features of DNA are significant in the basic chromatin organization, but are not the only determinant. (C) 2004 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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