Journal
FEBS LETTERS
Volume 566, Issue 1-3, Pages 43-47Publisher
WILEY
DOI: 10.1016/j.febslet.2004.03.104
Keywords
steroid receptor RNA activator; non-coding RNA; RNA interference; steroid receptor RNA activator homologue; steroid receptor RNA activator protein
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The steroid receptor RNA activator (SRA) has previously been characterized as belonging to the growing family of functional non-coding RNAs. However, we recently reported the Western blot detection of a putative endogenous SRA protein (SRAP) in breast cancer cells. Herein, we successfully suppressed the expression of this protein through specific RNA interference assay, unequivocally confirming its existence. Moreover, using database searches and Western blot analysis, we also showed that SRAP is highly conserved among chordata. Overall, our results suggest that SRA is the first example of a new class of functional RNAs also able to encode a protein. (C) 2004 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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