Journal
AQUACULTURE RESEARCH
Volume 47, Issue 5, Pages 1631-1638Publisher
WILEY
DOI: 10.1111/are.12624
Keywords
Echinacea purpurea; growth; antioxidant activity; microRNA; crucian carp (Carassius auratus)
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Funding
- National Natural Science Foundation of China [31302213, 31001117]
- earmarked fund for China Agriculture Research System [CARS-46-43]
- Project on the Integration of Industry, Education and Research of Guangdong Province
- Education Ministry of China [2012B091100421]
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Echinacea purpurea (EP), a globally popular herbal medicine, has been used to treat various diseases in human and animals. However, little has been reported about its effects in fish. In this study, crucian carp (Carassius auratus) were selected to evaluate the effects of EP on growth performance and antioxidant response and the expressions of microRNAs. The results showed EP could stimulate the growth of crucian carp with the best effect was observed at dose of 4 g kg(-1). In serum, the content of hydroxyl radical (center dot OH) and malondialdehyde (MDA) decreased by EP supplementation, whereas the activities of superoxide dismutase (SOD), catalase (CAT) and glutathione reductase (GR) increased. Similarly, the content of center dot OH decreased, and the activities of CAT, GPX and GR increased in liver of crucian carp. Furthermore, in livers of crucian carp, EP supplements upregulated the expressions of the microRNAs (miR-16, miR-21, miR-125b, miR-146a, miR-155, miR-181a and miR-223), which had been confirmed to participate in regulating antioxidant and immune function in mammals. Our results suggest EP supplements in diets stimulated growth performance and antioxidant response of crucian carp. In liver, the upregulation of specific miRNAs may participate in the antioxidant effects of EP diets.
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