Journal
ONCOGENE
Volume 23, Issue 24, Pages 4341-4345Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/sj.onc.1207671
Keywords
Runx; CD4; silencing; epigenetics
Ask authors/readers for more resources
Runx family proteins have the potential for either activating or suppressing gene expression in a context-dependent manner. There are several mechanisms by which transcriptional repression can occur. A wide range of locus inactivation, that is often called gene silencing, is thought to be achieved by chromatin modi. cations. Recently, Runx family proteins were found to have an essential role in either temporal transcriptional repression or irreversible epigenetic silencing at the CD4 locus through binding to a CD4 silencer at different stages of development. These findings link Runx function to epigenetic gene regulation, and shed new light on the mechanisms by which Runx represses target gene expression.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available