Journal
TETRAHEDRON LETTERS
Volume 45, Issue 22, Pages 4311-4314Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2004.04.010
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A new compound indigocarpan (1) and the known compound mucronulatol (2) were isolated from chloroform extracts of Indigofera aspalathoides. Their structures were established by spectroscopic methods, including single-crystal X-ray analysis (in the case of 1). The isolates were evaluated for cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) inhibitory activities and antioxidant properties. The new compound 1 showed significant COX-1 inhibition (IC50 30.5 muM) and its in vivo anti-inflammatory activity was found to be comparable to that of ibuprofen. Molecular docking Studies revealed the binding orientations of 1 in the active sites of COX-1 and COX-2. (C) 2004 Elsevier Ltd. All rights reserved.
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