Journal
ONCOGENE
Volume 23, Issue 24, Pages 4238-4248Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/sj.onc.1207763
Keywords
Runx1; Runx2; Runx3; CBF beta; AML1; hematopoiesis; hematopoietic stem cells
Funding
- Medical Research Council [MC_U137970202] Funding Source: Medline
- Medical Research Council [MC_U137970202] Funding Source: researchfish
- MRC [MC_U137970202] Funding Source: UKRI
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Core binding factors are heterodimeric transcription factors containing a DNA binding Runx1, Runx2, or Runx3 subunit, along with a non DNA binding CBFbeta subunit. All four subunits are required at one or more stages of hematopoiesis. This review describes the role of Runx1 and CBFb in the initiation of hematopoiesis in the embryo, and in the emergence of hematopoietic stem cells. We also discuss the later stages of hematopoiesis for which members of the core binding factor family are required, as well as the recently described roles for these proteins in autoimmunity.
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