Journal
NEUROLOGY
Volume 62, Issue 10, Pages 1869-1871Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1212/01.WNL.0000125323.15458.3F
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Funding
- NIA NIH HHS [P30AG10133] Funding Source: Medline
- NINDS NIH HHS [1 K23 NS02227-01] Funding Source: Medline
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In this retrospective analysis of 443 Alzheimer disease ( AD) patients from a 30-week tacrine trial, change in Alzheimer's Disease Assessment Scale score from baseline to final value was significantly associated with a total serum cholesterol/ APOE genotype interaction. Disease progression in the no-APOE epsilon4 allele/high-cholesterol subgroup was greater than in the normal-cholesterol subgroups with or without epsilon4. Cholesterol levels and APOE genotype may interact to affect AD progression. The results are consistent with preclinical data on cholesterol's effects in AD.
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