Journal
NEURON
Volume 42, Issue 4, Pages 619-634Publisher
CELL PRESS
DOI: 10.1016/S0896-6273(04)00247-8
Keywords
-
Categories
Funding
- NHLBI NIH HHS [HL41370, R01 HL041370, R37 HL041370] Funding Source: Medline
- NIMH NIH HHS [MH64109, R01 MH064109] Funding Source: Medline
- NINDS NIH HHS [NS14610, R37 NS014610, R01 NS014610] Funding Source: Medline
Ask authors/readers for more resources
Noradrenergic, serotonergic, and histaminergic neurons are continuously active during waking, reduce discharge during NREM sleep, and cease discharge during REM sleep. Cataplexy, a symptom associated with narcolepsy, is a waking state in which muscle tone is lost, as it is in REM sleep, while environmental awareness continues, as in alert waking. In prior work, we reported that, during cataplexy, noradrenergic neurons cease discharge, and serotonergic neurons greatly reduce activity. We now report that, in contrast to these other monoaminergic REM-off cell groups, histamine neurons are active in cataplexy at a level similar to or greater than that in quiet waking. We hypothesize that the activity of histamine cells is linked to the maintenance of waking, in contrast to activity in noradrenergic and serotonergic neurons, which is more tightly coupled to the maintenance of muscle tone in waking and its loss in REM sleep and cataplexy.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available