Journal
NEUROSCIENCE LETTERS
Volume 362, Issue 3, Pages 232-235Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neulet.2004.03.019
Keywords
age; paw withdrawal frequency; hemisection; locomotor; spinal cord injury
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Funding
- NINDS NIH HHS [NS 39161, NS 11255] Funding Source: Medline
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We tested the effect of age at the time of spinal cord injury (SCI) on locomotor recovery, in open field tests, and mechanical hyperalgesia, using paw withdrawal frequency (PWT) in response to noxious mechanical stimuli, in male Sprague-Dawley rats after spinal hemisection at T13 in young (40 days), adult (60 days) and middlc-age (1 year) groups. Behavioral outcomes were measured weekly for 4 weeks in both SCI and sham groups. Following SCI the young and adult groups recovered significantly more locomotor function, at a more rapid rate, than did the middle-age roup. The PWF of the young group was significantly increased, the adult group was significantly decreased, and the middleage group showed no significant change in fore- and hindlimbs when compared to other age groups, pre-injury and sham controls. These results support age-dependent behavioral outcomes after SCI. (C) 2004 Elsevier Ireland Ltd. All rights reserved.
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