Journal
NEUROSCIENCE LETTERS
Volume 362, Issue 3, Pages 189-192Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neulet.2004.02.070
Keywords
anxiety; emotion; genotyping; amygdala; positron emission tomography; serotonin transporter; social phobia
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A functional polymorphism in the promoter region of the human serotonin transporter (5-HTT) gene has been related to negative affect and amygdala activity. We studied amygdala activation during social anxiety provocation in relation to affective ratings and 5-HTT genetic variation.[H-2 O-15]positron emission tomography was used to estimate amygdala blood flow during private and public speaking (baseline and anxiety conditions) in 17 patients with social phobia. Genotyping identified patients with long and short alleles in the promoter region of the 5-HTT. Individuals with one or two copies of the short allele exhibited significantly increased levels of anxiety-related traits, state anxiety, and enhanced right amygdala responding to anxiety provocation, compared with subjects homozygous for the long allele. Thus, 5-HTT genetic variation was associated with symptom severity and amygdala excitability in social phobia. (C) 2004 Elsevier Ireland Ltd. All rights reserved.
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