Journal
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
Volume 1663, Issue 1-2, Pages 52-60Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbamem.2004.03.012
Keywords
integrin; sialic acid; glycosylation; adhesion; fibronectin
Categories
Funding
- NCI NIH HHS [R01 CA84248] Funding Source: Medline
- NIAMS NIH HHS [5 P60 AR20614-23] Funding Source: Medline
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Although it has been known for many years that beta1 integrins undergo differential glycosylation in accordance with changes in cell phenotype, the potential role of N-glycosylation as a modulator of integrin function has received little attention. One reason for the relatively limited interest in this topic likely relates to the fact that much of the prior research was correlative in nature. However, new results now bolster the hypothesis that there is a causal relationship between variant glycosylation and altered integrin activity. In this review, the evidence for variant glycosylation as a regulatory mechanism for beta1 integrins are summarized, with particular emphasis on: (1) outlining the instances in which cell phenotypic variation is associated with differential beta1 glycosylation, (2) describing the specific alterations in glycan structure that accompany phenotypic changes and (3) presenting potential mechanisms by which variant glycosylation might regulate integrin function. (C) 2004 Elsevier B.V. All fights reserved.
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