Journal
CANCER LETTERS
Volume 208, Issue 2, Pages 179-186Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2004.01.033
Keywords
(-)-epigallocatechin gallte (EGCG); doxorubicin; resistance; tumor; nude mice
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A human carcinoma xenograft model was established with resistant KB-A-1 cell line in order to investigate whether (-)-epigallocatechin gallte (EGCG) can reverse doxorubicin (DOX) resistance in vivo. EGCG could sensitize the tumors to DOX as indicated by a considerable reduction of tumor weights. The combination of DOX with EGCG increased the DOX concentration by 51% in the tumors, and increased DOX-induced apoptosis in the tumors compared with DOX alone. In addition, the combination schedules appeared to be well tolerated. We conclude that EGCG could chemosensitize resistant tumor cells to DOX in vivo through an increase in the accumulation of DOX in the tumors. (C) 2004 Elsevier Ltd. All rights reserved.
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