Journal
SCIENCE
Volume 304, Issue 5675, Pages 1301-1305Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1095087
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- NIGMS NIH HHS [GM52703] Funding Source: Medline
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Networks of cross-linked and bundled actin. laments are ubiquitous in the cellular cytoskeleton, but their elasticity remains poorly understood. We show that these networks exhibit exceptional elastic behavior that reflects the mechanical properties of individual. laments. There are two distinct regimes of elasticity, one reflecting bending of single. laments and a second reflecting stretching of entropic fluctuations of filament length. The mechanical stiffness can vary by several decades with small changes in cross-link concentration, and can increase markedly upon application of external stress. We parameterize the full range of behavior in a state diagram and elucidate its origin with a robust model.
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