Journal
BRAIN RESEARCH
Volume 1009, Issue 1-2, Pages 129-136Publisher
ELSEVIER
DOI: 10.1016/j.brainres.2004.02.055
Keywords
cytokine; sleep deprivation; EEG power; EEG coherence; sleep factor
Categories
Funding
- NINDS NIH HHS [NS31453, NS25378] Funding Source: Medline
Ask authors/readers for more resources
Sleep is posited to be a fundamental property of groups of highly interconnected neurons and regulated in part by activity-dependent sleep regulatory substances such as tumor necrosis factor alpha (TNFalpha). We show that the unilateral local application of TNFalpha onto the somatosensory cortex of rats induced state- and frequency-dependent EEG asymmetries. In contrast, the unilateral injection of a TNFalpha inhibitor, a TNFalpha soluble receptor, attenuated sleep deprivation-enhanced EEG slow wave power ipsilaterally during non-rapid eye movement sleep (NREMS) but not during REMS or waking. Results are consistent with the notion that sleep begins with state changes occurring within small groups of highly interconnected neurons and is driven in part by the local production of sleep regulating substances. (C) 2004 Elsevier B.V All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available