Journal
BRAIN RESEARCH
Volume 1009, Issue 1-2, Pages 223-227Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.brainres.2004.02.048
Keywords
amygdala; rostral ventromedial medulla; periaqueductal grays opioid
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Funding
- NIDA NIH HHS [DA05608] Funding Source: Medline
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Microinjections of morphine into the basolateral (BLa) and medial (MEa) nuclei of the amygdala differentially affect rostral ventromedial medulla (RVM) neuronal activity and nocifensive behaviors. PAG lesions attenuated or blocked the effects of both BLa and MEa morphine on RVM cell activity, and interfered with the behavioral antinociception produced by BLa infusions. These results demonstrate that the influences from both the BLa and MEa to the RVM are relayed via the PAG. (C) 2004 Elsevier B.V. All rights reserved.
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