Journal
ACCOUNTS OF CHEMICAL RESEARCH
Volume 37, Issue 6, Pages 387-395Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ar030249w
Keywords
-
Categories
Ask authors/readers for more resources
This Account outlines the unique features of the boron-mediated aldol reaction of carboxylic esters, which include (i) facile isomerization of E-enolate to Z-enolate and (ii) formation of a doubly borylated enolate upon enolization of acetate esters. The first carbon-bound boron enolates were spectroscopically characterized, and they appeared to be responsible for these unique properties. Furthermore, complementary anti- and syn-selective boron-mediated asymmetric aldol reactions of chiral propionate esters have been developed. A novel double aldol reaction of acetate esters has been discovered, and a plausible mechanism of the double aldol reaction is proposed.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available