Journal
ELECTROPHORESIS
Volume 25, Issue 10-11, Pages 1397-1412Publisher
WILEY
DOI: 10.1002/elps.200305822
Keywords
capillary electrophoresis; DNA typing; forensic science; review; short tandem repeat
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DNA typing with short tandem repeat (STR) markers is now widely used for a variety of applications including human identification. Capillary electrophoresis (CE) instruments, such as the ABI Prism 310 and ABI 3100 Genetic Analyzers, are the method of choice for many laboratories performing STR analysis. This review discusses issues surrounding sample preparation, injection, separation, detection, and interpretation of STIR results using CE systems. Requirements for accurate typing of STR alleles are considered in the context of what future analysis platforms will need to increase sample throughput and ease of use.
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