Journal
JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS
Volume 277, Issue 1-2, Pages 165-174Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jmmm.2003.10.022
Keywords
magnetic nanoparticles; histidine; rhenium-188; tricarbonyl complex; radiolabeling
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Magnetite nanoparticles coated with silica were synthesized and characterized by electron microscopic methods (SEM and TEM) and crystal structure analysis (XRD). After surface modification with an amino silane coupling agent, N-[3-(trimethyoxysilyl) propyl]-ethylenediamine (SG-Si900), histidine was covalently linked to the amine group using glutaraldehyde as cross.-linker. The magnetic nanoparticles were then radiolabeled with Re-188 with a labeling yield of 91.4 +/- 0.3% and good stability in vitro. The labeling mechanism is suggested as fac-[Re-188(CO)(3)(H2O)(3)](+) core complexed with imidazolyl groups. (C) 2003 Elsevier B.V. All rights reserved.
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