Journal
CURRENT OPINION IN NEUROBIOLOGY
Volume 14, Issue 3, Pages 318-327Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.conb.2004.05.008
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Funding
- NIGMS NIH HHS [T32-GM08554] Funding Source: Medline
- NIMH NIH HHS [R01-MH63232] Funding Source: Medline
- NINDS NIH HHS [P01-NS44282, R01-NS37508] Funding Source: Medline
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A prominent role for calcium/calmodulin-dependent protein kinase II (CaMKII) in regulation of excitatory synaptic transmission was proposed two decades ago when it was identified as a major postsynaptic density protein. Since then, fascinating mechanisms optimized to fine-tune the magnitude and locations of CaMKII activity have been revealed. The importance of CaMKII activity and autophosphorylation to synaptic plasticity in vitro, and to a variety of learning and memory paradigms in vivo has been demonstrated. Recent progress brings us closer to understanding the regulation of dendritic CaMKII activity, localization, and expression, and its role in modulating synaptic transmission and cell morphology.
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