4.2 Article Proceedings Paper

5-spirocyclopropane isoxazolidines as versatile intermediates in organic synthesis

Journal

MONATSHEFTE FUR CHEMIE
Volume 135, Issue 6, Pages 649-669

Publisher

SPRINGER WIEN
DOI: 10.1007/s00706-003-0150-x

Keywords

thermal rearrangement; small ring system; nitrogen heterocycles; ring contraction; ring expansion

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The review outlines the various different azaheterocycles available from 5-spirocyclopropane isoxazolidines. These compounds can be regarded as versatile direct precursors of tetrahydro-, dihydropyridone and azetidinone derivatives. The current scope and limitations, and the selectivity aspects of the different processes are discussed therein.

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