Journal
CURRENT OPINION IN NEUROBIOLOGY
Volume 14, Issue 3, Pages 370-378Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.conb.2004.05.005
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Funding
- NIAAA NIH HHS [AA13481] Funding Source: Medline
- NIDA NIH HHS [P50 DA005010, DA05010] Funding Source: Medline
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Mu opioid receptors mediate positive reinforcement following direct (morphine) or indirect (alcohol, cannabinoids, nicotine) activation, and our understanding of mu receptor function is central to the development of addiction therapies. Recent data obtained in native neurons confirm that mu receptor signaling and regulation are strongly agonist-dependent. Current functional mapping reveals morphine-activated neurons in the extended amygdala and early genomic approaches have identified novel mu receptor-associated proteins. A classification of about 30 genes either promoting or counteracting the addictive properties of morphine is proposed from the analysis of knockout mice data. The targeting of effectors or regulatory proteins, beyond the mu receptor itself, might provide valuable strategies to treat addictive disorders.
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