Journal
JOURNAL OF VIROLOGY
Volume 78, Issue 11, Pages 6061-6066Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.78.11.6061-6066.2004
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Funding
- NIAID NIH HHS [R01 AI023946, AI23946] Funding Source: Medline
- NIGMS NIH HHS [R01 GM063228, GM63228] Funding Source: Medline
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Coronavirus discontinuous transcription uses a highly conserved sequence (CS) in the joining of leader and body RNAs. Using a full-length infectious construct of transmissable gastroenteritis virus, the present study demonstrates that subgenomic transcription is heavily influenced by upstream flanking sequences and supports a mechanism of transcription attenuation that is regulated in part by a larger domain composed of primarily upstream flanking sequences which select appropriately positioned CS elements for synthesis of subgenomic RNAs.
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