Journal
JOURNAL OF VIROLOGY
Volume 78, Issue 11, Pages 6048-6054Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.78.11.6048-6054.2004
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Cleavage of the mouse hepatitis coronavirus strain A59 spike protein was blocked in a concentration-dependent manner by a peptide furin inhibitor, indicating that furin or a furin-like enzyme is responsible for this process. While cell-cell fusion was clearly affected by preventing spike protein cleavage, virus-cell fusion was not, indicating that these events have different requirements.
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