Journal
PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS
Volume 70, Issue 6, Pages 539-552Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.plefa.2003.12.001
Keywords
glioma; gamma-linolenic acid; free radicals; polyunsaturated fatty acids; tumoricidal; cancer; angiogenesis; arachidonic acid; eicosapentaenoic acid; docosahexaenoic acid; prostaglandins; anti-oxidants; apoptosis
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Malignant gliomas are among the most devastating of cancers and are a major cause of mortality in a young population with a median survival time of 9 months following cytoreductive surgery, radiotherapy and chemotherapy. Recent studies showed that polyunsaturated fatty acids especially gamma-linolenic acid (GLA) have selective tumoricidal action especially against malignant glioma cells both in vitro and in vivo. Limited open label clinical studies showed that intratumoral injection/infusion of GLA is safe and effective against malignant gliomas. In view of this, large-scale, double blind studies are needed to establish the usefulness of GLA in the treatment of malignant brain tumors. (C) 2004 Elsevier Ltd. All rights reserved.
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