Journal
INFECTION AND IMMUNITY
Volume 72, Issue 6, Pages 3650-3654Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/IAI.72.6.3650-3654.2004
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Treponema denticola and its major outer sheath protein (Msp) induce actin reorganization in fibroblasts. We adapted a barbed-end labeling/imaging assay to monitor Msp-induced subcortical actin filament assembly in neutrophils and fibroblasts. Msp, at an actin-reorganizing concentration, inhibited migration of these dissimilar cell types, whose cytoskeletal functions in locomotion and phagocytosis are crucial for immunity and healing of peripheral infections.
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