Interpenetrated network-type hydrogels based on gellan and poly(vinyl alcohol) for inclusion and release of cephotaxime

The study discusses achieving a polymer-drug system in which the macromolecular support is an interpenetrated network based on gellan (Gel) and poly(vinyl alcohol) (PVA). The drug (cephotaxime, CEF) has been included through a diffusion process, from an aqueous solution into a high swelling degree hydrogel. The kinetics of drug inclusion and release, from these macromolecular supports with different swelling characteristics in aqueous media has been studied.