Journal
JOURNAL OF CLINICAL PERIODONTOLOGY
Volume 31, Issue 6, Pages 449-453Publisher
WILEY
DOI: 10.1111/j.1600-051X.2004.00499.x
Keywords
cytokine; destruction; proinflammatory; tissue; tumour necrosis factor alpha
Categories
Ask authors/readers for more resources
Background: Immunorelevant gene polymorphisms might influence the susceptibility for periodontal disease. The present study assessed the frequency of a promoter polymorphism (-308G-to-A) of the tumour necrosis factor (TNF)alpha gene in patients with periodontitis and controls. Methods: Eighty-one patients with generalized chronic periodontitis and 80 healthy controls were genotyped for the -308 polymorphism of the TNFalpha gene by PCR amplification and subsequent restriction fragment length polymorphism analysis. The diagnosis of chronic periodontitis was made for each subject on basis of standardized clinical and radiographic criteria. Results: In patients with peridontitis and controls, the frequency of the TNFalpha-308 A allele was comparable (19.1% [31/162] versus 13.8% [22/160]; p=0.193). Conclusion: The present study revealed no association between the -308 TNFalpha gene polymorphism and periodontal disease.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available