Journal
JOURNAL OF CLINICAL VIROLOGY
Volume 30, Issue 2, Pages 196-204Publisher
ELSEVIER
DOI: 10.1016/j.jcv.2003.10.007
Keywords
norovirus; CHH; recombinant; BMT; T cell immunodeficiency
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We have demonstrated the long-term excretion of a stable recombinant norovirus in a patient with cartilage hair hypoplasia (CHH), with a T cell immunodeficiency, following bone marrow transplantation (BMT). The patient excreted an ARG320/1999/US-like recombinant norovirus (rGII-3) for 156 days during a period of immune reconstitution. The child was symptomatic during the period of virus shedding. It is not known if the child acquired the recombinant strain or if recombination occurred in vivo. (C) 2003 Elsevier B.V. All rights reserved.
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